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1199590-75-4

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1199590-75-4 Structure

1199590-75-4 Structure
IdentificationBack Directory
[Name]

GNE 220
[CAS]

1199590-75-4
[Synonyms]

GNE 220
5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-
[Molecular Formula]

C25H26N8
[MDL Number]

MFCD31619318
[MOL File]

1199590-75-4.mol
[Molecular Weight]

438.528
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

11.21±0.50(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2934999090
Hazard InformationBack Directory
[Uses]

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
[IC 50]

MAP4K4: 7 nM (IC50); MAP4K5: 9 nM (IC50); MAP4K6: 1.1 μM (IC50)
[storage]

Store at -20°C
[References]

[1] Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30. DOI:10.1038/nature14323
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