| Identification | Back Directory | [Name]
SULFURETIN | [CAS]
120-05-8 | [Synonyms]
SULFURETIN
SULPHURETIN
SULFURETIN hplc
SULFURETIN WITH HPLC
6,3',4'-TRIHYDROXYAURONE
3',4',6-TRIHYDROXYAURONE
3',4',6-Trihydroxybenzalcoumaranone
2-(3,4-Dihydroxybenzylidene)-6-hydroxy-3(2H)-benzofuranone
2-(3,4-dihydroxybenzylidene)-6-hydroxy-2H-benzofuran-3-one
(Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-2H-benzofuran-3-one
(Z)-2-[(3,4-Dihydroxyphenyl)methylene]-6-hydroxy-3(2H)-benzofuranone
2-[(Z)-(3,4-Dihydroxyphenyl)methylene]-6-hydroxybenzofuran-3(2H)-one
3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-, (2Z)- | [EINECS(EC#)]
204-366-4 | [Molecular Formula]
C15H10O5 | [MDL Number]
MFCD00017304 | [MOL File]
120-05-8.mol | [Molecular Weight]
270.24 |
| Hazard Information | Back Directory | [Uses]
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2]. | [Definition]
ChEBI: Sulfuretin is a member of 1-benzofurans. | [Biological Activity]
Anti-adipogenicantineoplastic activityantioxidative stressAnti-Inflammatory | [in vivo]
Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1]. | Animal Model: | Pathogen-free male BALB/c mice (7-8 weeks old)[1] | | Dosage: | 40 μg/kg | | Administration: | A single intraperitoneal injection was administered 2 h after the last OVA challenge | | Result: | Suppressed OVA-induced chemotaxis and airway inflammation.
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| [References]
[1] Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. DOI:10.1016/j.bbrc.2010.08.014
[2] Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771. |
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