120128-14-5

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120128-14-5 Structure

Identification	Back Directory
[Name] thrazarine
[CAS] 120128-14-5
[Synonyms] FR-900840 thrazarine Antibiotic FR-900840 O-[(R)-2-Diazo-3-hydroxy-1-oxobutyl]-L-serine
[Molecular Formula] C7H11N3O5
[MDL Number] MFCD00873761
[MOL File] 120128-14-5.mol
[Molecular Weight] 217.18

Chemical Properties	Back Directory
[Melting point ] 123-125 °C

Hazard Information	Back Directory
[Uses] Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research[1].
[References] [1] Kameyama T, et al. Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1988 Nov;41(11):1561-7. DOI:10.7164/antibiotics.41.1561

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