| Identification | Back Directory | [Name]
1-Phenylpyrazole-4-boronic acid | [CAS]
1201643-70-0 | [Synonyms]
1-Phenylpyrazole-4-boronic acid
(1-phenylpyrazol-4-yl)boronic acid
1-Phenyl-1H-pyrazole-4-boronic acid
(1-Phenyl-1H-pyrazol-4-yl)boronic acid
Boronic acid, B-(1-phenyl-1H-pyrazol-4-yl)- | [Molecular Formula]
C9H9BN2O2 | [MDL Number]
MFCD11044914 | [MOL File]
1201643-70-0.mol | [Molecular Weight]
187.99 |
| Chemical Properties | Back Directory | [Boiling point ]
393.1±34.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
7.44±0.10(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Definition]
ChEBI: (1-Phenyl-1H-pyrazol-4-yl)boronic acid is a ring assembly and a member of pyrazoles. | [Synthesis]
General procedure for the synthesis of 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester from 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester: To a solution of 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester (0.6 g, 3.1 mmol) in acetone/water (30 mL, v/v = 1:1) was added sodium periodate (NaIO4, 2.0 g, 9.3 mmol) and ammonium acetate (NH4OAc, 0.54 g, 7.1 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to give a residue. The residue was purified by column chromatography (eluent: methanol/dichloromethane = 1:5) to afford the target product 1-phenyl-1H-pyrazole-4-boronic acid (0.3 g, 89% yield) as a light yellow solid. Mass spectrometry (MS) analysis showed a molecular ion peak (m/z) of 189 ([M+H]+). | [References]
[1] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 134-135 |
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