| Identification | Back Directory | [Name]
2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride | [CAS]
1202237-87-3 | [Synonyms]
(S)-2-(2-AMINO-3-(3-FLUOROPHENYL)PROPYL)ISOINDOLINE-1,3-DIONE HCL
2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride
1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-, hydrochloride (1:1) | [Molecular Formula]
C17H16ClFN2O2 | [MOL File]
1202237-87-3.mol | [Molecular Weight]
334.773 |
| Hazard Information | Back Directory | [Synthesis]
Tert-butyl (S)-(1-(1,3-dioxoisoindolin-2-yl)-3-(3-fluorophenyl)propan-2-yl)carbamate (9.0 g, 22.6 mmol) was used as a raw material and dissolved in dichloromethane (DCM, 200 mL). To this solution was slowly added a dioxane solution (56 mL, 226 mmol) of 4 M hydrochloric acid at room temperature. The reaction mixture was stirred for 12 hours at room temperature. Upon completion of the reaction, the mixture was filtered and the solid was washed with dichloromethane (50 mL) to afford the white solid product (S)-2-(2-amino-3-(3-fluorophenyl)propyl)isoindoline-1,3-dione hydrochloride (7.8 g, 99% yield). The product was analyzed by LCMS (ES), m/z 349 (M + H)+. | [References]
[1] Patent: WO2009/158371, 2009, A1. Location in patent: Page/Page column 34
[2] Patent: WO2009/158372, 2009, A1. Location in patent: Page/Page column 30
[3] Patent: US2013/96144, 2013, A1. Location in patent: Paragraph 0248-0250
[4] Patent: WO2009/158374, 2009, A2. Location in patent: Page/Page column 30 |
|
|