| Identification | Back Directory | [Name]
[2H7]-Ibudilast | [CAS]
1204192-90-4 | [Synonyms]
[2H7]-Ibudilast
Ibudilast D7Q: What is
Ibudilast D7 Q: What is the CAS Number of
Ibudilast D7 Q: What is the storage condition of
Ibudilast D7 | [Molecular Formula]
C14H18N2O | [MOL File]
1204192-90-4.mol | [Molecular Weight]
230.31 |
| Hazard Information | Back Directory | [Uses]
Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46(3):404-11. DOI:10.1016/j.neuropharm.2003.09.009 |
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