| Identification | Back Directory | [Name]
IDO inhibitor 1 | [CAS]
1204669-37-3 | [Synonyms]
HY-15689
IDO inhibitor 1
HY-15689;INCB 024360
IDO inhibitor 1,Epacadostat
Epacadostat (INCB024360, IDO inhibitor 1)
N-(3-bromo-4-fluorophenyl)-N-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide | [Molecular Formula]
C11H13BrFN7O4S | [MDL Number]
MFCD26142934 | [MOL File]
1204669-37-3.mol | [Molecular Weight]
438.233 |
| Hazard Information | Back Directory | [Biological Activity]
ido inhibitor 1 is a potent and novel indoleamine-2,3 dioxygenase (ido) inhibitor with ic50 value <100 nm.ido is an enzyme that catalyzes the degradation of the essential amino acid l-tryptophan to n-formylkynurenine and permits tumor cells to escape the immune system. | [References]
[1]. andrew p. combs, et al. 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase. patent numeber: ep 2315756 a2http://www. google.com/patents/ep2315756a2?cl=en |
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SPIRO PHARMA
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BOC Sciences
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Twochem Co.Ltd
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parabiochem
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