| Identification | Back Directory | [Name]
2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE | [CAS]
120595-72-4 | [Synonyms]
6-Chloro-2'-deoxyguanosine
2-AMINO-6-CHLOROPURINE-2'-DEOXYRIBOSIDE
2-AMINO-6-CHLOROPURINE-2'-DEOXY-D-RIBOFURANOSIDE
2-Amino-6-chloropurine-9-beta-D-(2'-deoxy)riboside
2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside
2-Amino-6-chloro-9-(β-D-2-deoxyribofuranosyl)purine
2-Amino-6-chloro-9-(β-D-2-deoxyribofuranosyl)
purine
2-Amino-6-chloro-9-(2'-deoxy-b-D-ribofuranosyl)purine
2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE
9H-Purin-2-amine, 6-chloro-9-(2-deoxy-β-D-erythro-pentofuranosyl)-
6-Chloro-9-(2-deoxy-β-D-erythro -pentofu ranosyl)-9H -purin-2-amine
(2R,3S,5S)-5-(2-AMino-6-chloro-9H-purin-9-yl)-2-(hydroxyMethyl)tetrahydrofuran-3-ol | [Molecular Formula]
C10H12ClN5O3 | [MDL Number]
MFCD00672274 | [MOL File]
120595-72-4.mol | [Molecular Weight]
285.69 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [InChI]
InChI=1/C10H12ClN5O3/c11-8-7-9(15-10(12)14-8)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/s3 | [InChIKey]
LEDIVMUMDVEFRG-FLEGHBDQNA-N | [SMILES]
N1(C=NC2C(Cl)=NC(N)=NC1=2)[C@H]1C[C@H](O)[C@@H](CO)O1 |&1:11,13,15,r| |
| Hazard Information | Back Directory | [Uses]
2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
|
|