| Identification | Back Directory | [Name]
benzyl(2S,5R)-5-amino-2-methylpiperidine-1-carboxylate | [CAS]
1207853-23-3 | [Synonyms]
EOS-61887
EOS-62319
(2S,5R)-5-amino-2-methylpiperidine-1-carboxylate
benzyl(2S,5R)-5-amino-2-methylpiperidine-1-carboxylatehydrochloride
(2S,5R)-Benzyl 5-amino-2-methylpiperidine-1-carboxylate hydrochloride
(2S,5R)-5-amino-2-methylpiperidine-1-carboxylic acid benzyl ester hydrochloride | [EINECS(EC#)]
210-077-2 | [Molecular Formula]
C14H20N2O2 | [MDL Number]
MFCD22689536 | [MOL File]
1207853-23-3.mol | [Molecular Weight]
248.321 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1/C14H20N2O2.ClH/c1-11-7-8-13(15)9-16(11)14(17)18-10-12-5-3-2-4-6-12;/h2-6,11,13H,7-10,15H2,1H3;1H/t11-,13+;/s3 | [InChIKey]
QDXRLZBFPKVDHC-VCSCPQGNNA-N | [SMILES]
C(N1C[C@H](N)CC[C@@H]1C)(=O)OCC1C=CC=CC=1.Cl |&1:3,7,r| |
| Hazard Information | Back Directory | [Synthesis]
Preparation of compound 30d: Benzyl (2S,5R)-5-amino-2-methylpiperidine-1-carboxylic acid benzyl ester hydrochloride 30c (20 g, 0.057 mol) was dissolved in HCl(g)/Et2O (4N, 100 mL) and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was filtered to afford (2S,5R)-5-amino-2-methylpiperidine-1-carboxylic acid benzyl ester 30d hydrochloride as a white solid (16 g, 73% yield). The product was characterized by 1H NMR (400 MHz, DMSO): δppm 1.097-1.080 (d, 3H), 1.627-1.573 (m, 2H), 1.849-1.749 (m, 2H), 2.991-2.978 (m, 2H), 4.158-4.139 (d, 1H), 4.317-4.292 ( m, 1H), 5.072 (s, 2H), 7.386-7.305 (m, 5H), 8.392 (s, 3H). | [References]
[1] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 135-137 |
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