| Identification | Back Directory | [Name]
Tepilamide fumarate | [CAS]
1208229-58-6 | [Synonyms]
Tepilamide fumarate
2-Butenedioic acid (2E)-, 1-[2-(diethylamino)-2-oxoethyl] 4-methyl ester | [Molecular Formula]
C11H17NO5 | [MDL Number]
MFCD28502262 | [MOL File]
1208229-58-6.mol | [Molecular Weight]
243.26 |
| Chemical Properties | Back Directory | [Boiling point ]
347.5±22.0 °C(Predicted) | [density ]
1.131±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 125 mg/mL (513.85 mM) | [form ]
Solid | [pka]
-1.04±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tepilamide fumarate (XP-23829; PPC-06) is an oral fumaric acid ester, acts as a proagent of Monomethyl fumarate.html" class="link-product" target="_blank">Monomethyl fumarate (HY-103252), and is used in the research of moderate to severe chronic plaque psoriasis. Tepilamide fumarate can enhance the effectiveness of oncolytic viruses[1][2]. | [References]
[1] Mrowietz U, et al. Tepilamide Fumarate (PPC-06) Extended Release Tablets in Patients with Moderate-to-Severe Plaque Psoriasis: Safety and Efficacy Results from the Randomized, Double-blind, Placebo-controlled AFFIRM Study. J Clin Aesthet Dermatol. 2022 Jan;15(1):53-58. PMID:35309277
[2] Akram Alwithenani, et al. Tepilamide Fumarate as a Novel Potentiator of Virus-Based Therapy. Viruses. 2024 Jun 5;16(6):920. DOI:10.3390/v16060920 |
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