| Identification | Back Directory | [Name]
withangulatin A | [CAS]
120824-03-5 | [Synonyms]
withangulatin A
PLPXOWZTDPJPHC-ISIACCJKSA-N
Ergosta-2,16,24-trien-26-oic acid, 15-(acetyloxy)-5,6-epoxy-4,14,22-trihydroxy-1-oxo-, δ-lactone, (4β,5α,6β,15α,22R)- | [Molecular Formula]
C30H38O8 | [MOL File]
120824-03-5.mol | [Molecular Weight]
526.62 |
| Hazard Information | Back Directory | [Description]
Withangulatin A is a natural potent antitumor agent, targeting sarco/endoplasmic reticulum calcium-ATPase (SERCA). | [Uses]
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function[1]. | [Definition]
ChEBI: Withangulatin A is a withanolide. | [References]
[1] Lijuan Sun, et al. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem. 2010 Feb 15;109(3):532-41. DOI:10.1002/jcb.22430 |
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