| Identification | Back Directory | [Name]
1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,14,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,3,6a,10b-tetramethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aR)- | [CAS]
120849-18-5 | [Synonyms]
Physalin O
1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,14,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,3,6a,10b-tetramethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aR)- | [Molecular Formula]
C28H32O10 | [MOL File]
120849-18-5.mol | [Molecular Weight]
528.55 |
| Hazard Information | Back Directory | [Uses]
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 μM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities[1][2]. | [Definition]
ChEBI:Physalin O is a physalin. | [References]
[1] Kuo PC, et al. Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. Org Lett. 2006 Jul 6;8(14):2953-6. DOI:10.1021/ol060801s
[2] Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77(5):441-7. DOI:10.1016/j.steroids.2011.11.016 |
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