| Identification | Back Directory | [Name]
2-(5-chloro-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine | [CAS]
1210-81-7 | [Synonyms]
ST1936
ST1936,ST-1936
ST 1936 oxalate
1H-Indole-3-ethanamine, 5-chloro-N,N,2-trimethyl-
5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
2-(5-chloro-2-methyl-1H-indol-3-yl)-N,N-dimethylethanamine | [Molecular Formula]
C13H17ClN2 | [MDL Number]
MFCD22201006 | [MOL File]
1210-81-7.mol | [Molecular Weight]
236.74 |
| Chemical Properties | Back Directory | [Boiling point ]
377.0±42.0 °C(Predicted) | [density ]
1.165±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥5mg/mL (warmed) | [form ]
powder | [pka]
16.90±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Serotonin 5-HT(6) receptor agonists and antagonists have been proposed as possible useful compounds in the treatment of psychiatric disorders such as depression (1). ST 1936 Oxalate is a 5-HT(6) receptor agonist and may be a potential antidepressant/anti-anhedonic drug (1,2). | [in vivo]
ST1936 (5, 10, 20 mg/kg; i.p.) increases in a dose dependent manner extracellular dopamine (DA) and NA levels in the prefrontal cortex (PFCX)[4].
ST1936 (5, 10, 20 mg/kg; i.p.) increases extracellular DA and NA levels in the nucleus accumbens (NAc) core. Doses of 10 mg/kg increases dialysate DA (peak: 179%) while higher dose increases both DA and NA dialysates (201% and 231%, respectively). Doses of 5 mg/kg does not produce any effect[4]. | [IC 50]
5-HT6 Receptor: 13 nM (Ki); 5-HT7 Receptor: 168 nM (Ki); 5-HT2B Receptor: 245 nM (Ki); α1-adrenergic receptor: 390 nM (Ki, rat); α2-adrenergic receptor: 300 nM (Ki, rat); α2-adrenergic receptor: 300 nM (Ki, human) |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
GZanlihe
|
| Tel: |
13928234501 18098185186 |
| Website: |
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