| Identification | Back Directory | [Name]
CS-1 | [CAS]
1210283-33-2 | [Synonyms]
CS-1, Anti proliferative agent
3,3'-((3,4,5-trifluorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
2H-1-Benzopyran-2-one, 3,3'-[(3,4,5-trifluorophenyl)methylene]bis[4-hydroxy- | [Molecular Formula]
C25H13F3O6 | [MOL File]
1210283-33-2.mol | [Molecular Weight]
466.36 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable di-coumarin compound that selectively inhibits γ-secretase-mediated production of Aβ42 over Aβ38, Aβ40, and Notch1 both in cell-free APP cleavage assays (IC50 = 0.07, 0.71, 0.31, and 1.77 µM, respectively) and in human and murine cultures (100% blockage of Aβ42 production and no effect against the rest at 30 µM) by altering the S1′ and S3′ pockets within the presenilin substrate binding site via an allosteric, non-substrate-competitive mechanism. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
|