| Identification | Back Directory | [Name]
IEM 1460 | [CAS]
121034-89-7 | [Synonyms]
IEM 1460
5-(1-adamantylmethylamino)pentyl-trimethylazanium:bromide:hydrobromide
N,N,N-TRIMETHYL-5-[(TRICYCLO[3.3.1.13,7]DEC-1-YLMETHYL)AMINO]-1-PENTANAMINIUMBROMIDE HYDROBROMIDE
N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromidehydrobromide | [Molecular Formula]
C19H38Br2N2 | [MDL Number]
MFCD09878250 | [MOL File]
121034-89-7.mol | [Molecular Weight]
454.34 |
| Hazard Information | Back Directory | [Description]
IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM). It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain. | [Uses]
IEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents. | [Biological Activity]
Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo . | [storage]
Room temperature (desiccate) | [References]
[1] FRIEDRICH SCHLESINGER. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors[J]. British Journal of Pharmacology, 2009, 145 5: 656-663. DOI: 10.1038/sj.bjp.0706233 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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