| Identification | Back Directory | [Name]
L 656748 | [CAS]
121124-29-6 | [Synonyms]
L 656748
EMaMectin B1a
Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)- | [Molecular Formula]
C49H75NO13 | [MOL File]
121124-29-6.mol | [Molecular Weight]
886.12 |
| Chemical Properties | Back Directory | [Boiling point ]
935.0±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
12.42±0.70(Predicted) | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically. | [Uses]
Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. | [storage]
Store at -20°C, protect from light | [References]
[1] H. MROZIK. Discovery of novel avermectins with unprecedented insecticidal activity[J]. Experientia. Supplementum, 1989, 42 1: 315-316. DOI: 10.1007/bf01951823
[2] G R DAWSON. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 295 3: 1051-1060.
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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