| Identification | Back Directory | [Name]
CALPHOSTIN C | [CAS]
121263-19-2 | [Synonyms]
UCN-1028C
PKF 115-584
CALPHOSTIN C
Cladochrome E
He Ding C Carver
(R)-Calphostin C
Calphostin C,98%
Calphostin CUCN-1028C
UCN 1028 C, PKF 115-384
Calphostin C(UCN 1028C, PKF 115584)
CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES
C,CalphostinCfroMCladosporiuMcladosporioide
CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES
4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione
1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione
2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER
(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester
Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer | [Molecular Formula]
C44H38O14 | [MDL Number]
MFCD00133155 | [MOL File]
121263-19-2.mol | [Molecular Weight]
790.76 |
| Chemical Properties | Back Directory | [Appearance]
Dark red solid | [Boiling point ]
1039.8±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMF: 1 mg/mL
| [form ]
powder
| [pka]
7.30±0.20(Predicted) | [color ]
red to brown
| [biological source]
microbial (Cladosporium cladosporioides) | [InChIKey]
SRJYZPCBWDVSGO-UHFFFAOYSA-N | [SMILES]
COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24 |
| Hazard Information | Back Directory | [Chemical Properties]
Dark red solid | [Uses]
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. | [Uses]
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines. | [Biological Activity]
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM). | [Biochem/physiol Actions]
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro. | [storage]
+4°C (desiccate) |
|
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Lynnchem
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