| Identification | Back Directory | [Name]
1,2,4-Triazolo[4,3-a]pyrimidine-6-acetamide, N-[5-[(2-fluorophenyl)methyl]-2-thiazolyl]-1,5-dihydro-3,7-dimethyl-5-oxo- | [CAS]
1214561-09-7 | [Synonyms]
HPK1-IN-8
1,2,4-Triazolo[4,3-a]pyrimidine-6-acetamide, N-[5-[(2-fluorophenyl)methyl]-2-thiazolyl]-1,5-dihydro-3,7-dimethyl-5-oxo- | [Molecular Formula]
C19H17FN6O2S | [MOL File]
1214561-09-7.mol | [Molecular Weight]
412.44 |
| Hazard Information | Back Directory | [Uses]
HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1. | [Biological Activity]
HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1. | [References]
[1]. Wang W, et al. Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay. Biochemistry. 2021 Oct 19;60(41):3114-3124. |
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