| Identification | Back Directory | [Name]
(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid | [CAS]
1215204-46-8 | [Synonyms]
N-Propargyl-lysine
N-propargyloxycarbonyl-L-lysine
Click-Amino-Acid / PrK - HCl-salt
N6-((prop-2-yn-1-yloxy)carbonyl)-L-lysine
N6-[(2-propynyloxy)carbonyl]-L-lysine HCl
L-Lysine, N6-[(2-propyn-1-yloxy)carbonyl]-
(2S)-2-amino-6-{[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid | [Molecular Formula]
C10H16N2O4 | [MDL Number]
MFCD22393078 | [MOL File]
1215204-46-8.mol | [Molecular Weight]
228.24 |
| Hazard Information | Back Directory | [Uses]
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2]. N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2].
Labeling of N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH)-carrying cellular proteins, such as Sec61β, Htt74Q and the histone H3 variant H3.3, with a sensitive Raman tag by click chemistry for molecular hyperspectral SRS imaging[1]. | [References]
[1]. Kyung Jin Lee, et al. Site-Specific Labeling of Proteins Using Unnatural Amino Acids. Mol Cells. 2019 May 31;42(5):386-396. [2]. Enke HEIKE, et al. Modified microcystins and nodularins.WO2018206715A2 |
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