| Identification | Back Directory | [Name]
METOCLOPRAMIDE-D3 | [CAS]
1216522-89-2 | [Synonyms]
METOCLOPRAMIDE-D3
[2H3]-Metoclopramide
4-AMino-5-chloro-N-[2-(diethylaMino)ethyl]-2-(Methoxy-d3)benzaMide
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(trideuteriomethoxy)benzamide
Metoclopramide D3Q: What is
Metoclopramide D3 Q: What is the CAS Number of
Metoclopramide D3 Q: What is the storage condition of
Metoclopramide D3 Q: What are the applications of
Metoclopramide D3 | [Molecular Formula]
C14H19ClD3N3O2 | [MDL Number]
MFCD08063630 | [MOL File]
1216522-89-2.mol | [Molecular Weight]
302.81 |
| Chemical Properties | Back Directory | [Melting point ]
143-148°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White |
| Hazard Information | Back Directory | [Description]
Metoclopramide-d3 is intended for use as an internal standard for the quantification of metoclopramide by GC- or LC-MS. Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents. | [Chemical Properties]
White Crystalline Solid | [Uses]
Labelled dopamine D2 receptor antagonist. A labelled substituted benzamide with neuroleptic activity. Antiemetic. | [storage]
Store at -20°C |
|
| Company Name: |
TOSUN PHARM
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020-61855200 13326451905 |
| Website: |
www.toref.cn/ |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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