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1217022-63-3

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1217022-63-3 Structure

1217022-63-3 Structure
IdentificationBack Directory
[Name]

PTC-209 (hydrobroMide)
[CAS]

1217022-63-3
[Synonyms]

CS-1314
PTC-209HBR
PTC-209 (hydrobroMide)
N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-1,3-thiazol-2-amine
2-Thiazolamine, N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-, hydrobromide
[Molecular Formula]

C17H13Br2N5OS.HBr
[MDL Number]

MFCD28143911
[MOL File]

1217022-63-3.mol
[Molecular Weight]

576.103
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

≥ 22.9mg/mL in DMSO with gentle warming
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

PTC-209 is a potent and selective BMI-1 inhibitor. It results in irreversible reduction of cancer-initiating cells (CICs).
[in vivo]

PTC-209 (60 mg/kg body weight; subcutaneously; once a day for 11 days) significantly reduces tumor volume[2].

Animal Model:Nude mice (male, aged 8-10 weeks, HCT1116 cell-derived tumor)[1]
Dosage:60 mg/kg body weight
Administration:Subcutaneously; once a day for 11 days
Result:Significantly reduced tumor volume.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

PTC-209 (hydrobroMide)(1217022-63-3)1HNMR
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