| Hazard Information | Back Directory | [Description]
LQB-118 is an orally active pterocarpanquinone molecule with potential anticancer activity. LQB-118 may have potential therapeutic value for leukemia, being able to overcome multiple resistance mechanisms. | [Uses]
LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases[1][2][3][4]. | [References]
[1] Bernardo PS, et al. LQB?118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020 Jan;43(1):346-357. DOI:10.3892/or.2019.7402
[2] Martino T, et al. LQB-118 Suppresses Migration and Invasion of Prostate Cancer Cells by Modulating the Akt/GSK3β Pathway and MMP-9/Reck Gene Expression. Anticancer Res. 2023 Jan;43(1):359-367. DOI:10.21873/anticanres.16171
[3] Lima éA, et al. The pterocarpanquinone LQB 118 inhibits inflammation triggered by zymosan in vivo and in vitro. Int Immunopharmacol. 2020 Jun;83:106399. DOI:10.1016/j.intimp.2020.106399
[4] Ribeiro GA, et al. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother. 2013 Apr;68(4):789-99. DOI:10.1093/jac/dks498 |
|
|