| Identification | Back Directory | [Name]
1-Aminoadamantane-2,2,2′,2′,2″,2″-d6 | [CAS]
1219805-53-4 | [Synonyms]
[2H6]-Amantadine
Adamantanamine-d6
1-Aminoadamantane-2,2,2′,2′,2″,2″-d6
Adamantanamine-d6 Solution, 100μg/mL
Amantadine-d6 (1-Amino Adamantane-d6)
Amantadine-d6
DISCONTINUED, offer A575822 / A575823
1-Aminoadamantane-2,2,2',2',2'',2''-d6 Solution in Methanol, 100μg/mL
Amantadine D6Q: What is
Amantadine D6 Q: What is the CAS Number of
Amantadine D6 Q: What is the storage condition of
Amantadine D6 Q: What are the applications of
Amantadine D6 | [Molecular Formula]
C10H17N | [MDL Number]
MFCD19704894 | [MOL File]
1219805-53-4.mol | [Molecular Weight]
151.25 |
| Hazard Information | Back Directory | [Uses]
Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. DOI:10.1007/s10156-003-0262-6
[3] Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 201278(14):1096-1099. DOI:10.1212/WNL.0b013e31824e8f0d
[4] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan57(1-2):41-52. DOI:10.1016/s0166-3542(02)00199-7
[5] Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 2413(4):539. DOI:10.3390/v13040539
[6] Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct121(4):773-85. DOI:10.1097/ALN.0000000000000352
[7] Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 201536(3):904-910. DOI:10.3892/ijmm.2015.2289 |
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