1219811-83-2

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1219811-83-2 Structure

Chemical Properties	Back Directory
[Boiling point ] 640.2±65.0 °C(Predicted)
[density ] 1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] 7.11±0.40(Predicted)

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[Uses] CaSR antagonist-1 is a calcium sensing receptor (CaSR) antagonist with an IC50 value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis[1].
[References] [1] Ramanjulu JM, et al. Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. ACS Med Chem Lett. 2021 Aug 10;12(9):1396-1404. DOI:10.1021/acsmedchemlett.1c00187

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