| Identification | Back Directory | [Name]
pivalyloxymethyl butyrate | [CAS]
122110-53-6 | [Synonyms]
Pivanex
Brn 4861411
pivalyloxymethyl butyrate
((2,2-Dimethylpropanoyl)oxy)methyl butanoate
Butanoic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester | [Molecular Formula]
C10H18O4 | [MDL Number]
MFCD00209896 | [MOL File]
122110-53-6.mol | [Molecular Weight]
202.25 |
| Chemical Properties | Back Directory | [Boiling point ]
249.3±13.0 °C(Predicted) | [density ]
1.008±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
oil | [color ]
colorless or slightly yellow |
| Hazard Information | Back Directory | [Uses]
AN-9 is an HDAC inhibitor with antimetastic and antiangiogenic properties. Histone deacetylase inhibitors in cancer therapy. Formaldehyde-releasing prodrugs for localized anticancer chemotherapy. | [in vivo]
Pivanex (AN9, 200 mg/kg, b.i.d, daily) significantly improves the survival of SMN7 SMA mice. Pivanex (AN9) treatment also marked delays the end stage of disease as defined by the onset of body mass loss[3]. | Animal Model: | SMN7 SMA mice (SMN2+/+; SMN7+/+; mSmn?/?)[3]. | | Dosage: | 200 mg/kg. | | Administration: | Oral administration, b.i.d, at 09.00 and 17.00 daily. | | Result: | Improved the mean lifespan of treated SMN7 SMA mice by 84.6%.
Delayed the onset of body mass loss in SMN7 SMA mice by 94.9%.
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| [IC 50]
HDAC; Bcr-Abl |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|