| Identification | Back Directory | [Name]
TC-I 2014 | [CAS]
1221349-53-6 | [Synonyms]
TC-I 2014
TCI 2014,TC I 2014
VSMFCZZEKTVDHM-UHFFFAOYSA-N
3-[7-(TRIFLUOROMETHYL)-5-[2-(TRIFLUOROMETHYL)PHENYL]-1H-BENZIMIDAZOL-2-YL]-1-OXA-2-AZASPIRO[4.5]DEC-2-ENE
1-Oxa-2-azaspiro[4.5]dec-2-ene, 3-[7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]- | [Molecular Formula]
C23H19F6N3O | [MDL Number]
MFCD30182291 | [MOL File]
1221349-53-6.mol | [Molecular Weight]
467.41 |
| Chemical Properties | Back Directory | [Boiling point ]
564.3±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.01±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TC-I 2014 is a potent TRPM8 antagonist exhibiting antiallodynic properties in pain models. | [in vivo]
TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1]. | Animal Model: | TC-I 2014 (10 mg/kg, Orally once) completely prevents icilin-induced WDS[1]. | | Dosage: | 3, 5.6, 10 mg/kg. | | Administration: | Orally once. | | Result: | Produced greater than 90% inhibition at 3, 5.6, and 10 mg/kg administered 2 h prior to icilin challenge. |
| [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|