| Identification | Back Directory | [Name]
ML234 | [CAS]
1222800-79-4 | [Synonyms]
ML234
ML324
ML243
CS-2198
5-Pyrroledione
ML234 USP/EP/BP
NCGC00183808-01
ML324(CID-44143209)
ML-324;ML324;ML 324
N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide
Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)- | [Molecular Formula]
C21H23N3O2 | [MDL Number]
MFCD28053518 | [MOL File]
1222800-79-4.mol | [Molecular Weight]
349.43 |
| Chemical Properties | Back Directory | [Melting point ]
>187oC (dec.) | [Boiling point ]
590.1±50.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
4.71±0.40(Predicted) | [color ]
white to light brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
ML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the latent state in sensory neurons.1 | [Uses]
ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice. | [References]
1) Liang?et al. (2013),?Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency; Sci. Transl. Med.,?5?167ra5 |
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