| Identification | Back Directory | [Name]
5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole | [CAS]
1222810-74-3 | [Synonyms]
VU591
VU591 >=98% (HPLC)
2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole)
2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole)
1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-
2,2'-(Oxybis(methylene))bis(5-nitro-1H-benzo[d]imidazole)
2,2-(Oxydimethanediyl)Bis(5-Nitro-1H-Benzimidazole)(WXC03621)
6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole
5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
6-NITRO-2-[(6-NITRO-1H-BENZIMIDAZOL-2-YL)METHOXYMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE | [Molecular Formula]
C16H12N6O5 | [MDL Number]
MFCD20264924 | [MOL File]
1222810-74-3.mol | [Molecular Weight]
368.3 |
| Chemical Properties | Back Directory | [Boiling point ]
777.9±55.0 °C(Predicted) | [density ]
1.641±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥12mg/mL | [form ]
powder | [pka]
7.88±0.30(Predicted) | [color ]
white to tan | [InChI]
1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20) | [InChIKey]
ZQPXNYLXYNRFNP-UHFFFAOYSA-N | [SMILES]
[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1 |
| Hazard Information | Back Directory | [Uses]
VU591 may be used in cell signaling studies. | [Biological Activity]
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) th at is closely related to VU590. Unlike VU590VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1causing 17% inhibition at 10 uM. | [in vivo]
VU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST[2]. | Animal Model: | Male ICR mice[2] | | Dosage: | 1.842 μg | | Administration: | i.c.v.; 1.842 μg; | | Result: | Showed antidepressive effect in the tail suspension test (TST). |
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| Company Name: |
Wuxi AppTec
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| Tel: |
022-59987777 13552403979 |
| Website: |
www.labnetwork.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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