| Identification | Back Directory | [Name]
Diethyl Trimethylsilyl Phosphite | [CAS]
122289-10-5 | [Synonyms]
DIETHYL TRIMETHYLSILYL PHOSPHITE
Phosphinous acid, diethyl-, trimethylsilyl ester (9CI) | [Molecular Formula]
C7H19OPSi | [MOL File]
122289-10-5.mol | [Molecular Weight]
178.28 |
| Hazard Information | Back Directory | [Uses]
Diethyl Trimethylsilyl Phosphite is used for nucleophilic, trivalent phosphorus reagent capable of forming a diethyl phosphonate derivative by displacement reaction or silylphosphonylation of multiple bond functionalities such as aldehydes and ketones, both saturated and unsaturated.
| [Synthesis Reference(s)]
1.Liotta, D.; Sunay, U.; Ginsberg, S. JOC 1982, 47, 2227.
2.Creary, X.; Geiger, C. C.; Hilton, K. JACS 1983, 105, 2851.
| [Synthesis]
Diethyl Trimethylsilyl Phosphite is generally synthesized by reacting the sodium salt of Diethyl Phosphonite with Chlorotrimethylsilane in ether.1 Alternatively, the reagent has been prepared by reacting diethyl phosphonite with chlorotrimethylsilane in ether/TEA.2 | [storage]
Diethyl Trimethylsilyl Phosphite is susceptible to hydrolysis and should be prepared immediately prior to use.
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