| Identification | Back Directory | [Name]
(-)-Trichostatin A | [CAS]
122292-85-7 | [Synonyms]
(-)-Trichostatin A
[S-(E,E)]-(-)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [S-(E,E)]- (9CI) | [Molecular Formula]
C17H22N2O3 | [MOL File]
122292-85-7.mol | [Molecular Weight]
302.37 |
| Hazard Information | Back Directory | [Uses]
(S)-Trichostatin A ((S)-TSA) is a HDAC6-selective inhibitor with IC50s of 9.88 nM and 11.1 nM for Zebrafish HDAC6 and Human HDAC6, respectively. (S)-Trichostatin A weakly inhibits other human HDACs[1]. | [IC 50]
hHDAC6: 11.1 nM (IC50); Zebrafish HDAC6: 9.88 nM (IC50); hHDAC1: 206.3 nM (IC50); hHDAC2: 612.65 nM (IC50); hHDAC3: 320.8 nM (IC50); hHDAC4: 6341 nM (IC50); hHDAC5: 6325 nM (IC50); hHDAC7: 1823.5 nM (IC50); hHDAC8: 312.2 nM (IC50); hHDAC9: 4824 nM (IC50); hHDAC10: 403.35 nM (IC50); hHDAC11: 2684 nM (IC50) | [References]
[1] Yasuyuki Miyake, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016 Sep;12(9):748-54. DOI:10.1038/nchembio.2140 |
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