| Identification | Back Directory | [Name]
5-AMINO-4-FLUORO-2-METHYLPHENOL | [CAS]
122455-85-0 | [Synonyms]
4-Amino-5-fluoro-o-cresol
4-Amino-5-fluoro-o-methylphenol
5-AMINO-4-FLUORO-2-METHYLPHENOL
2-Methyl-4-fluoro-5-aminophenol
3-Amino-4-fluoro-6-methylphenol
5-Amino-4-fluoro-o-cresol (OH=1)
2-Fluoro-5-hydroxy-4-methylaniline
5-Amino-4-fluoro-2-methylphenol98%
5-Amino-4-fluoro-2-methylphenol 98%
Phenol,5-amino-4-fluoro-2-methyl-
2-Fluoro-5-hydroxy-4-methylaniline, 4-Amino-5-fluoro-2-hydroxytoluene | [Molecular Formula]
C7H8FNO | [MDL Number]
MFCD04972656 | [MOL File]
122455-85-0.mol | [Molecular Weight]
141.14 |
| Chemical Properties | Back Directory | [Melting point ]
147 °C | [Boiling point ]
271.0±35.0 °C(Predicted) | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
crystalline powder | [pka]
10.39±0.23(Predicted) | [color ]
Reddish light brown |
| Hazard Information | Back Directory | [Synthesis]
General procedure: a mixture of 4-fluoro-2-methyl-5-nitrophenol (1.4 g, 8.2 mmol) and 10% Pd/C (0.3 g, 20% w/w) in methanol (80 mL) was stirred for 2 hours under hydrogen atmosphere (30 psi). Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was concentrated to afford 5-amino-4-fluoro-2-methylphenol (0.68 g, 62% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.75 (s, 1H), 6.62 (d, J = 12.0 Hz, 1H), 6.21 (d, J = 8.1 Hz, 1H), 4.69 (s, 2H), 1.93 (s, 3H). | [References]
[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 69-70
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5369 - 5389
[3] Patent: US6362336, 2002, B1. Location in patent: Example 13 |
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