| Identification | Back Directory | [Name]
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[d]oxazol-2-amine | [CAS]
1224844-66-9 | [Synonyms]
2-aminobenzo[d]oxazol-5-ylboronic acid pinacol ester
5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazol-2-amine
2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoxazole
2-Benzoxazolamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzo[d]oxazol-2-amine
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazol-2-amine | [Molecular Formula]
C13H17BN2O3 | [MDL Number]
MFCD13182075 | [MOL File]
1224844-66-9.mol | [Molecular Weight]
260.1 |
| Chemical Properties | Back Directory | [Boiling point ]
411.7±37.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
1.75±0.10(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Uses]
2-Aminobenzo[d]oxazol-5-ylboronic acid pinacol ester is a useful intermediate for the development of small-molecular inhibitors (mTOR inhibitors) that targets cancer. | [Synthesis]
Specific operation: 127 g of 2-amino-5-bromobenzoxazole, 182 g of pinacol ester of bisboronic acid, 45 g of 1,1'-bis(diphenylphosphino)ferrocene palladium dichloride (dppf palladium chloride) and 180 g of potassium acetate were added to 2 L of 1,4-dioxane. The mixture was refluxed under nitrogen protection for 3 h. After cooling to room temperature, the mixture was filtered and the filtrate was concentrated to give the crude product 2-aminobenzoxazole-5-boronate. The crude product was dissolved in 500 mL of petroleum ether, stirred for 1 hr and filtered, and the filter cake was dried under vacuum at 50 °C to give 110 g of purified 2-amino benzoxazole-5-boronic acid ester in 89.5% yield. | [References]
[1] Patent: CN105130973, 2018, B. Location in patent: Paragraph 0053; 0069-0071
[2] Patent: WO2013/23184, 2013, A1. Location in patent: Paragraph 00233; 00234
[3] Patent: US2018/65983, 2018, A1
[4] Patent: WO2010/51042, 2010, A1. Location in patent: Page/Page column 27; 133; 219
[5] Patent: WO2013/71272, 2013, A1. Location in patent: Paragraph 00256-00275 |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
|