| Identification | Back Directory | [Name]
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) | [CAS]
122520-79-0 | [Synonyms]
Tyrphostin AG30(AG30)
(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP | [Molecular Formula]
C10H7NO4 | [MOL File]
122520-79-0.mol | [Molecular Weight]
205.17 |
| Chemical Properties | Back Directory | [Melting point ]
240 °C | [Boiling point ]
465.6±45.0 °C(Predicted) | [density ]
1.559±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: 125 mg/mL (609.25 mM) | [form ]
Yellow solid. | [pka]
0.81±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2]. | [storage]
Store at -20°C | [References]
[1] Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42. DOI:10.1002/j.1460-2075.1992.tb05225.x
[2] Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93. PMID:9149900
[3] Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3(3):151-62. DOI:10.1158/1541-7786.MCR-04-0130 |
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