1226767-94-7

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1226767-94-7 Structure

Identification	Back Directory
[Name] Bromo-PEG2-phosphonic acid ethyl ester
[CAS] 1226767-94-7
[Synonyms] Bromo-PEG2-phosphonic acid ethyl ester Bromo-PEG2-phosphonic acid diethyl ester Phosphonic acid, P-[2-[2-(2-bromoethoxy)ethoxy]ethyl]-, diethyl ester
[Molecular Formula] C10H22BrO5P
[MDL Number] MFCD25424121
[MOL File] 1226767-94-7.mol
[Molecular Weight] 333.16

Chemical Properties	Back Directory
[Boiling point ] 387.4±27.0 °C(Predicted)
[density ] 1.299±0.06 g/cm3(Predicted)
[form ] Liquid
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Description] Bromo-PEG2-phosphonic acid diethyl ester is a PEG linker containing a bromine group and a phosphonic acid diethyl ester. The bromine group is a good leaving group and participates in substitution reactions. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
[Uses] Bromo-PEG2-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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