| Identification | Back Directory | [Name]
2-chloro-3-fluoropyridin-4-aMine | [CAS]
1227577-03-8 | [Synonyms]
2-chloro-3-fluoropyridin-4-aMine
4-Amino-2-chloro-3-fluoropyridine
4-Pyridinamine, 2-chloro-3-fluoro-
2-Chloro-3-fluoro-pyridin-4-ylamine | [EINECS(EC#)]
818-063-5 | [Molecular Formula]
C5H4ClFN2 | [MDL Number]
MFCD16606117 | [MOL File]
1227577-03-8.mol | [Molecular Weight]
146.55 |
| Chemical Properties | Back Directory | [Boiling point ]
271.9±35.0 °C(Predicted) | [density ]
1.449±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
powder | [pka]
2.81±0.42(Predicted) | [color ]
Brown | [InChI]
InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9) | [InChIKey]
VUGYOFOYGPXOFL-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC(N)=C1F |
| Hazard Information | Back Directory | [Synthesis]
TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).
| [References]
[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 97
[2] Patent: US2015/203455, 2015, A1. Location in patent: Paragraph 0461; 0463
[3] Patent: WO2015/110378, 2015, A1. Location in patent: Paragraph 00263; 00312
[4] Patent: US9440929, 2016, B2. Location in patent: Page/Page column 59; 60
[5] Patent: WO2017/12647, 2017, A1. Location in patent: Paragraph 0502 |
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