| Identification | Back Directory | [Name]
MRS 2957 triethylammonium salt | [CAS]
1228271-30-4 | [Synonyms]
MRS 2957 triethylammonium salt
P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt
Uridine 5'-(tetrahydrogen triphosphate), P''→5'-ester with uridine 4-(O-methyloxime) | [Molecular Formula]
C19H28N5O20P3 | [MDL Number]
MFCD22989498 | [MOL File]
1228271-30-4.mol | [Molecular Weight]
739.37 |
| Chemical Properties | Back Directory | [density ]
2.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Powder | [pka]
0.94±0.50(Predicted) | [Water Solubility ]
Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
| Hazard Information | Back Directory | [Description]
Potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively. | [Uses]
MRS2957 is a P2Y6 receptor agonist that activates AMPK in pancreatic β-cells, promoting insulin secretion and reducing apoptosis, thereby holding potential as a therapeutic target for type 2 diabetes. | [References]
[1] AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells |
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