| Identification | Back Directory | [Name]
KY 05009 | [CAS]
1228280-29-2 | [Synonyms]
KY 05009
KY-05009
(KY05009
KY-05009 >=98% (HPLC)
KY-05009, 10 mM in DMSO
5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide
4-Thiazolecarboxamide, 5-[(4-methylbenzoyl)amino]-2-(phenylamino)-
5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide(WXC06259)
KY-05009,plasma-cells,MAP4K,Apoptosis,TNIK,inhibit,anti-cancer,KY05009,Wnt,caspase-dependent,MAPK Kinase Kinase Kinase,anti-proliferative,IL-6,Inhibitor,smyeloma,aminothiazole,KY 05009 | [Molecular Formula]
C18H16N4O2S | [MDL Number]
MFCD29059915 | [MOL File]
1228280-29-2.mol | [Molecular Weight]
352.41 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO:76.67(Max Conc. mg/mL);217.54(Max Conc. mM) | [form ]
powder | [color ]
light yellow to dark yellow | [InChI]
1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24) | [InChIKey]
WCEDGRTWDSHZHF-UHFFFAOYSA-N | [SMILES]
NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O |
| Hazard Information | Back Directory | [Uses]
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1]. | [Biochem/physiol Actions]
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells. | [IC 50]
TNIK: 100 nM (Ki) | [References]
[1] Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101. DOI:10.18632/oncotarget.17056 |
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