1228280-29-2

Directory

1228280-29-2 Structure

Identification	Back Directory
[Name] KY 05009
[CAS] 1228280-29-2
[Synonyms] KY 05009 KY-05009 (KY05009 KY-05009 >=98% (HPLC) KY-05009, 10 mM in DMSO 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide 4-Thiazolecarboxamide, 5-[(4-methylbenzoyl)amino]-2-(phenylamino)- 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide(WXC06259) KY-05009,plasma-cells,MAP4K,Apoptosis,TNIK,inhibit,anti-cancer,KY05009,Wnt,caspase-dependent,MAPK Kinase Kinase Kinase,anti-proliferative,IL-6,Inhibitor,smyeloma,aminothiazole,KY 05009
[Molecular Formula] C18H16N4O2S
[MDL Number] MFCD29059915
[MOL File] 1228280-29-2.mol
[Molecular Weight] 352.41

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMSO:76.67(Max Conc. mg/mL);217.54(Max Conc. mM)
[form ] powder
[color ] light yellow to dark yellow

Hazard Information	Back Directory
[Uses] KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1].
[Biochem/physiol Actions] KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
[IC 50] TNIK: 100 nM (Ki)
[References] [1] Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101. DOI:10.18632/oncotarget.17056

Spectrum Detail	Back Directory
[Spectrum Detail] KY 05009(1228280-29-2)¹HNMR

1228280-29-2 suppliers list

Company Name:	Shanghai EFE Biological Technology Co., Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

Company Name:	Shanghai YuanYe Biotechnology Co., Ltd.
Tel:	021-61312847; 18021002903
Website:	http://www.shyuanye.com

Company Name:	Tianjin Kailiqi Biotechnology Co., Ltd.
Tel:	15076683720
Website:	http://www.cw-bio.com

Company Name:	Shanghai Hongye Biotechnology Co. Ltd
Tel:	400-9205774
Website:	www.glpbio.cn

Company Name:	ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel:	18818260767
Website:	http://www.chemegen.com

Company Name:	cjbscvictory
Tel:	13348960310
Website:	https://www.weikeqi-biotech.com/

Company Name:	Jinan Jiuli Biotechnology Co. , Ltd.
Tel:	15865264761
Website:	www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

Company Name:	RD International Technology Co., Limited
Tel:	18024082417
Website:	www.ruidiresearch.com

Company Name:	Hunan Hui Bai Yi New Materials Co., Ltd
Tel:	0745-2866551 19976851779
Website:	www.huibaishiji.com/

Tags:1228280-29-2 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login