| Identification | Back Directory | [Name]
2-Chloropyrimidine-4-boronicacid | [CAS]
1228431-85-3 | [Synonyms]
2-Chloropyrimidine-4-boronicacid
(2-ChloropyriMidin-4-yl)boronic acid
(2-Chloro-4-pyrimidinyl)boronic acid
B-(2-Chloro-4-pyrimidinyl)boronic Acid
Boronic acid, B-(2-chloro-4-pyrimidinyl)- | [Molecular Formula]
C4H4BClN2O2 | [MDL Number]
MFCD08703257 | [MOL File]
1228431-85-3.mol | [Molecular Weight]
158 |
| Questions And Answer | Back Directory | [Uses]
2-Chloropyrimidine-4-boronic acid is an organic intermediate commonly used in metal coupling reactions such as the Suzuki reaction. Literature reports that 2-chloropyrimidine-4-boronic acid can be used to synthesize EGFR and ERK kinase inhibitors. EGFR is a member of the erbB (type I) subfamily of RTKs, along with erbB-2, erbB-3, and erbB-4. These receptors are activated by ligands that induce dimerization of their receptors. While EGFR-EGFR homodimers are commonly used for signal transduction, a more common process in this family is ligand-induced heterodimerization, resulting in a signal transduction entity such as EGFR:erbB-2 or erb-B2:erbB-3 with an appropriate ligand. | [Application]
2-Chloropyrimidine-4-boronic acid can be used to synthesize the EGFR kinase inhibitor intermediate 2-chloro-4-(1-methylimidazo[1,5-a]pyridin-3-yl)pyrimidine. |
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| Company Name: |
SynAsst Chemical.
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| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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