| Identification | Back Directory | [Name]
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem | [CAS]
1229246-07-4 | [Synonyms]
PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
2,4-Thiazolidinedione, 5-[[2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-5-bromophenyl]methylene]- | [Molecular Formula]
C19H10BrF6NO3S | [MDL Number]
MFCD32671969 | [MOL File]
1229246-07-4.mol | [Molecular Weight]
526.25 |
| Chemical Properties | Back Directory | [density ]
1.681±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 25mg/mL | [form ]
powder | [pka]
7.03±0.20(Predicted) | [color ]
light yellow |
| Hazard Information | Back Directory | [General Description]
A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 μM, respectively), but not that of LAR even at concentrations as high as 100 μM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal). |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck Millipore
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1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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