| Identification | Back Directory | [Name]
DIHYDREXIDINE HYDROCHLORIDE | [Synonyms]
DAR-0100
DihydrexidineHCl
Dihydrexidine hydroc
DIHYDROXIDINE HYDROCHLORIDE
DIHYDREXIDINE HYDROCHLORIDE
Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel-
(+/-)-TRANS-10,11-DIHYDROXY-5,6,6A,7,8,12B-HEXAHYDROBENZO[A]PHENANTHRIDINE HYDROCHLORIDE | [MDL Number]
MFCD01860859 | [MOL File]
123039-93-0.mol |
| Hazard Information | Back Directory | [Biological Activity]
A potent, full efficacy dopamine D 1 agonist which shows no agonist activity at peripheral D 2 receptors or adrenoceptors at doses which cause maximal stimulation of D 1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo . | [in vivo]
Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].
| Animal Model: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Dosage: | Adult male Sprague–Dawley rats (275-300 g)[4] | | Administration: | Intraperitoneal injection | | Result: | Produces prominent dopamine D1 receptor agonist effects in vivo |
| [IC 50]
D1 Receptor: 10 nM (IC50) |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|