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1231220-79-3

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1231220-79-3 Structure

1231220-79-3 Structure
IdentificationBack Directory
[Name]

LY2828360
[CAS]

1231220-79-3
[Synonyms]

CS-2878
LY2828360
8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine
9H-Purine, 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-
[Molecular Formula]

C22H27ClN6O
[MDL Number]

MFCD28010855
[MOL File]

1231220-79-3.mol
[Molecular Weight]

426.94
Chemical PropertiesBack Directory
[Boiling point ]

541.8±60.0 °C(Predicted)
[density ]

1.40±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Chloroform: 30 mg/ml
[form ]

A crystalline solid
[pka]

7.15±0.10(Predicted)
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

LY2828360(1231220-79-3)1HNMR
Hazard InformationBack Directory
[Biological Activity]

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist th at inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.
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