| Identification | Back Directory | [Name]
Abemaciclib Metabolites M2 | [CAS]
1231930-57-6 | [Synonyms]
Abemaciclib metabolite M2
Abemaciclib M2 Metabolite
Abemaciclib Metabolites M2
2H8]-Abemaciclib metabolite M2
5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-[5-(1-piperazinylmethyl)-2-pyridyl]pyrimidin-2-amine
2-Pyrimidinamine, 5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-N-[5-(1-piperazinylmethyl)-2-pyridinyl]- | [Molecular Formula]
C25H28F2N8 | [MOL File]
1231930-57-6.mol | [Molecular Weight]
478.54 |
| Chemical Properties | Back Directory | [Boiling point ]
690.9±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.01±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Des-Et-Abemaciclib is an impurity of Abemaciclib (A115153) is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells. | [in vivo]
Abemaciclib metabolite M2 (LSN2839567) is bound to plasma proteins in rat, dog and human (83-92%), lower than Abemaciclib (95-99%)[2].
?
Abemaciclib metabolite M2 is the most prominent (active and major) plasma metabolites in human[2]. | [IC 50]
CDK4: 1.2 nM (IC50); CDK6: 1.3 nM (IC50) | [storage]
Store at -20°C |
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