| Identification | Back Directory | [Name]
2,3,10-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-9-yl 3-fluorobenzenesulfonate | [CAS]
1233353-86-0 | [Synonyms]
Benzenesulfonic acid, 3-fluoro-, 5,8,13,13a-tetrahydro-2,3,10-trimethoxy-6H-dibenzo[a,g]quinolizin-9-yl ester | [Molecular Formula]
C26H26FNO6S | [MOL File]
1233353-86-0.mol | [Molecular Weight]
499.55 |
| Chemical Properties | Back Directory | [Boiling point ]
641.4±55.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.15±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PCSK9-IN-29 is a lipid-lowering agent. PCSK9-IN-29 can increase low-density lipoprotein receptor (LDLR) protein expression and decrease PCSK9 protein expression in hepG2 cells. PCSK9-IN-29 can reduce the levels of serum LDL-C, TC, and liver enzyme ALT in crab eating macaques fed a high-fat diet, lower body weight and fat, and increase bone mineral content. PCSK9-IN-29 can be used for research on non-alcoholic fatty liver disease and obesity[1]. | [References]
[1] Liu, jing wen, et al. 治疗 NASH、NAFLD 和肥胖症的化合物、组合物和方法. China, CN115279755A. 2022-11-01. |
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