| Identification | Back Directory | [Name]
FFN102 | [CAS]
1234064-11-9 | [Synonyms]
FFN102
FFN102 (Mini 102)
FFN102 >=98% (HPLC)
FFN-102 (trifluoroacetate salt) | [Molecular Formula]
C13H11ClF3NO5 | [MOL File]
1234064-11-9.mol | [Molecular Weight]
353.678 |
| Hazard Information | Back Directory | [Description]
FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 μM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 μM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 μM. | [Uses]
FFN-102 trifluoroacetate is an analogue of biogenic neurotransmitters. FFN-102 trifluoroacetate is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals[1]. | [References]
[1] Liu X, et al. A Dual Functional Electroactive and Fluorescent Probe for Coupled Measurements of Vesicular Exocytosis with High Spatial and Temporal Resolution. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2366-2370. DOI:10.1002/anie.201611145 |
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