| Identification | Back Directory | [Name]
N-Myristoyl-D-erythro-sphingosine | [CAS]
123408-74-2 | [Synonyms]
N-MYRISTOYL-D-ERYTHRO-SPHINGOSINE;C14 CERAMIDE (D18:1/14:0)
Tetradecanamide, N-[2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-, [R-(R*,S*)]- (9CI) | [Molecular Formula]
C32H63NO3 | [MOL File]
123408-74-2.mol | [Molecular Weight]
509.85 |
| Chemical Properties | Back Directory | [Boiling point ]
655.9±55.0 °C(Predicted) | [density ]
0.923±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
13.82±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
C14 Ceramide (d18:1/14:0) is suitable for use
- as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS2) for ceramide quantification from muscel biopsies
- in lipid monolayer preparation for biophysical studies
- in the morphological and dimensional evaluation studies
| [Biological Activity]
Ceramides regulate biological processes including proliferationdifferentiation and apoptosis. In the cystic fibrosis patientselevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|