| Identification | Back Directory | [Name]
Derazantinib | [CAS]
1234356-69-4 | [Synonyms]
ARQ-087
CPD1093
CS-2677
Derazantinib
Derazantinib (ARQ-087)
ARQ-087;ARQ087;ARQ 087;CPD1093
ARQ-087;ARQ087;DERAZANTINIB;ARQ 087
(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine
(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
Benzo[h]quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-, (6R)- | [Molecular Formula]
C29H29FN4O | [MDL Number]
MFCD30532770 | [MOL File]
1234356-69-4.mol | [Molecular Weight]
468.57 |
| Chemical Properties | Back Directory | [Boiling point ]
615.1±65.0 °C(Predicted) | [density ]
1.218±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:47.67(Max Conc. mg/mL);101.73(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);64.02(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM) | [form ]
A crystalline solid | [pka]
9.04±0.19(Predicted) | [color ]
White to yellow | [InChIKey]
KPJDVVCDVBFRMU-AREMUKBSSA-N | [SMILES]
N1=C2C(C[C@@H](C3=CC=CC=C3F)C3=CC=CC=C32)=CN=C1NC1=CC=CC(CCNCCOC)=C1 |
| Hazard Information | Back Directory | [Uses]
Derazantinib is an intermediate in the preparation of imidazopyridinyl compounds for treating proliferative disorders like cancer, Proteus syndrome and others. | [in vivo]
Derazantinib is effective at inhibiting tumor growth in FGFR2 altered, SNU-16 and NCI-H716, xenograft tumor models with gene amplifications and fusions[1]. Most of the embryos exhibit abnormal external phenotype (81.3%) in Derazantinib-injected wings, possibly due to inhibition of proliferation of limb bud mesenchyme. The wings are shorter and thinner, with skeletal phenotype typical for FGFR inhibition, where ulna and radius are shorter or smaller in size, or occasionally missing completely[2]. | [IC 50]
FGFR1: 4.5 nM (IC50); FGFR2: 1.8 nM (IC50); FGFR3: 4.5 nM (IC50) |
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| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|