| Identification | Back Directory | [Name]
(+)-trans-C75 | [CAS]
1234694-20-2 | [Synonyms]
(+)-trans-C75 Exclusive
(+)-trans-C-75,(+)transC75,(+) trans C75
3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2R,3S)- | [Molecular Formula]
C14H22O4 | [MOL File]
1234694-20-2.mol | [Molecular Weight]
254.32 |
| Hazard Information | Back Directory | [Description]
C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice. C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway. (+)-trans-C75 is an enantiomer of C75. Its biologicial activity has not been reported. | [Definition]
ChEBI: (2R,3S)-C75 is a 4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid that has 2R,3S-configuration. It is an enantiomer of a (2S,3R)-C75. |
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