| Identification | Back Directory | [Name]
PI3Kα inhibitor 1 | [CAS]
1235449-52-1 | [Synonyms]
CUDC-908
BEBT-908
PI3Kα-IN-243
PI3Kα inhibitor 1
BEBT-908(CUDC-908)
BEBT-908 / PI3Kα inhibitor 1
BEBT908;CUDC908;BEBT 908;CUDC 908
N-Hydroxy-2-[methyl[[2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]amino]-5-pyrimidinecarboxamide
N-hydroxy-2-[methyl({2-[6-(methylamino)pyridin-3-yl]-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl}methyl)amino]pyrimidine-5-carboxamide
N-Hydroxy-2-[[[2-[6-(methylamino)pyridin-3-yl]-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl][methyl]amino]pyrimidine-5-carboxamide | [Molecular Formula]
C23H25N9O3S | [MDL Number]
MFCD29924723 | [MOL File]
1235449-52-1.mol | [Molecular Weight]
507.57 |
| Chemical Properties | Back Directory | [density ]
1.461±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 37 mg/mL (72.90 mM) | [form ]
Solid | [pka]
7.77±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Ifupinostat is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) . | [IC 50]
PI3Kα: 0.1 μM (IC50); HDAC: 0.1 μM (IC50) | [References]
[1] Cai Xiong, et al. Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases. From U.S. Pat. Appl. Publ. (2012), US 20120088764 A1 20120412. |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|