| Identification | Back Directory | [Name]
NAB-14 | [CAS]
1237541-73-9 | [Synonyms]
NAB-14
4-((1H-Indol-7-yl)carbamoyl)phenyldiethylcarbamate
Carbamic acid, N,N-diethyl-, 4-[(1H-indol-7-ylamino)carbonyl]phenyl ester | [Molecular Formula]
C20H21N3O3 | [MOL File]
1237541-73-9.mol | [Molecular Weight]
351.4 |
| Chemical Properties | Back Directory | [Boiling point ]
489.5±41.0 °C(Predicted) | [density ]
1.277±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
14.14±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier[1]. | [Biological Activity]
NAB-14 is a negative allosteric modulator (NAM) selective for GluN2C/2D-containing NMDA glutamate receptors. NAB-14 was >800-fold selective for recombinant GluN2C/GluN2D over GluN2A/GluN2B in Xenopus oocytes and exhibited an IC50 value of 580 nM at recombinant GluN1/GluN2D receptors. | [in vivo]
NAB-14 (20 mg/kg; p.o.) shows high systemic exposure with peak brain free of 3.2 and 3.8 nM for mouse and rat, respectively[1]. | Animal Model: | Mice and rats[1] | | Dosage: | 20 mg/kg | | Administration: | P.o. | | Result: | Showed high systemic exposure with peak brain free of 3.2 and 3.8 nM for mouse and rat, respectively. |
| [References]
[1] Swanger SA, et al. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. DOI:10.1021/acschemneuro.7b00329 |
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|