| Identification | Back Directory | [Name]
2,4-Quinazolinediamine, N2-[3-(dimethylamino)propyl]-6,7-dimethoxy-N4-[1-(phenylmethyl)-4-piperidinyl]- | [CAS]
1239589-91-3 | [Synonyms]
LSD1-IN-20
2,4-Quinazolinediamine, N2-[3-(dimethylamino)propyl]-6,7-dimethoxy-N4-[1-(phenylmethyl)-4-piperidinyl]- | [Molecular Formula]
C27H38N6O2 | [MOL File]
1239589-91-3.mol | [Molecular Weight]
478.63 |
| Hazard Information | Back Directory | [Uses]
LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1]. | [References]
[1] Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410. DOI:10.1016/j.ejmech.2022.114410 |
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